丙硫多菌灵在水稻中的残留及长期膳食摄入风险评估
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

湖南省自然科学基金项目(2023JJ50072);大学生创新创业训练计划项目(s202410537049)


Residue and long-term dietary intake risk assessment of albendazole in rice
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    于2018年在杭州、合肥、长沙等12地开展丙硫多菌灵在水稻上的规范田间残留试验,建立测定水稻中丙硫多菌灵残留量的高效液相色谱法,定性、定量分析水稻样品中丙硫多菌灵的残留量,探究其在水稻中的残留水平、消解动力学及储藏稳定性情况,并评估其残留量对不同人群的长期膳食摄入风险。结果表明:在添加水平为0.05、0.10、1.00 mg/kg时,丙硫多菌灵在水稻中的平均添加回收率为78%~106%,相对标准偏差为4%~9%,定量限为0.05 mg/kg;在–20 ℃储存24周,所有水稻样品中的丙硫多菌灵降解率均不超过30%;丙硫多菌灵在稻谷中的残留消解过程符合一级动力学方程,消解半衰期为8.66~11.55 d;采用10%丙硫多菌灵悬浮剂施药,按有效成分用量150 g/hm2的剂量连续施药3次,施药间隔7 d,采收间隔期为14、21 d,收获的水稻糙米、稻壳、稻谷和稻秆中的丙硫多菌灵的最终残留量分别为≤0.08、≤0.08、≤0.07、≤0.20 mg/kg;针对中国、巴基斯坦、印度、孟加拉国、阿根廷和泰国不同年龄段与不同性别人群糙米膳食结构的摄入风险及中国总膳食摄入风险进行评估的风险商均低于100%,这表明消费者因食用糙米而摄入丙硫多菌灵所面临的长期膳食风险处于可接受水平。

    Abstract:

    Standardized field residue trials of albendazole on rice were conducted in 12 locations including Hangzhou, Hefei, and Changsha in 2018, where a high-performance liquid chromatography method was established to determine its residues in rice, enabling qualitative and quantitative analysis. This study also investigated albendazole residue levels, degradation kinetics, and storage stability in rice, and evaluated the long-term dietary intake risks of its residues for different populations. The results showed that at spiking levels of 0.05, 0.10, and 1.00 mg/kg, the average recovery rates of albendazole in rice ranged from 78% to 106% with relative standard deviations of 4% to 9%, and the limit of quantification was 0.05 mg/kg. Storage at –20 ℃ for 24 weeks resulted in ≤30% degradation across all rice samples. Its residue degradation in rice grains followed a first-order kinetic equation with half-lives of 8.66-11.55 days. Following three applications of a 10% albendazole suspension concentrate at an effective ingredient dosage of 150 g/hm2 with a 7-day application interval and pre-harvest intervals of 14 and 21 days, the final residues in brown rice, rice husk, rice grains, and rice straw were ≤0.08, ≤0.08, ≤0.07, ≤0.20 mg/kg, respectively. Risk assessments on dietary intake risks based on brown rice consumption patterns among different age and gender groups in China, Pakistan, India, Bangladesh, Argentina, and Thailand, as well as the total dietary intake risk in China yielded risk quotients below 100%, indicating acceptable long-term dietary exposure from brown rice consumption.

    参考文献
    相似文献
    引证文献
引用本文

谭敏仪,邓凯华,杨丽华*,段菁菁,姚思敏,胡洋洋.丙硫多菌灵在水稻中的残留及长期膳食摄入风险评估[J].湖南农业大学学报(自然科学版),2025,51(5):86-94.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2025-11-28
  • 出版日期:
文章二维码