In order to explore the expression pattern and function of the StZIP8-like gene, the full-length sequence of the StZIP8-like gene was cloned from potato. The structure, physicochemical properties, and genetic relationship of this gene were predicted by bioinformatics methods. The expression pattern of this gene under cadmium(Cd) stress was analyzed using the RT-qPCR technique. A fusion expression vector was constructed to analyze the subcellular localization of the StZIP8-like protein in tobacco leaves. Through a yeast heterologous expression experiment, the Cd transport function of StZIP8-like was analyzed. The results of structural analysis showed that the full-length sequence of StZIP8-like was 1 044 bp, encoding 347 amino acids, containing a ZIP conserved domain and 7 transmembrane domains. Phylogenetic analysis revealed that the StZIP8-like protein had a close genetic relationship with the ZIP8 proteins in tomato and tobacco. The results of subcellular localization indicated that the StZIP8-like protein was localized in the plasma membrane. The RT-qPCR results showed that StZIP8-like was highly expressed in the roots of potato seedlings, and Cd stress induced the upregulation of the expression of the StZIP8-like gene in the roots, stems, and leaves of potato. The yeast experiment showed that the yeast with overexpression of StZIP8-like was more sensitive to Cd and had Cd absorption and transport activity. The above results indicate that StZIP8-like is induced by Cd stress and may be involved in the process of Cd absorption in potato.