Two hundreds and eighty healthy 38-week-old yellow-feathered broiler breeder hens were selected and randomly divided into 4 groups. Group A was fed a basal diet, group B was fed a basal diet supplemented with 125 mg/kg vitamin-E(V-E), group C was fed a basal diet supplemented with 0.3 mg/kg of organic selenium, and group D was fed a diet supplemented with both 0.3 mg/kg of organic selenium and 125 mg/kg V-E for 42 days. On the 42nd day, 100 breeder eggs were collected from each group and incubated until emergence. Fertilization rate, hatch ability and chick weight were recorded and the prevalence of inflammations in muscular stomach and glandular stomach and the pathologic scores were determined in 1-day-old chicks. Additionally, 50 1-day-old chicks from each group were selected to measure the antioxidant capacity of the muscular stomach and the expression of inflammatory factors. The results showed that 1) groups B, C, D increased egg production rate, and the group C exhibited the most notable effect, with an increase of 5.31 percentage points in egg production rate and an increase of 4.69 percentage points in fertilization and hatching rate; 2) The prevalence of inflammations of muscular stomach and glandular stomach in 1-day-old chicks in groups B, C and D were reduced by 25.4%, 16.6% and 22.4%, respectively, compared to the group A; 3) In groups B, C and D, the T-AOC contents in muscular stomach of 1-day-old offspring were reduced by 32.54%, 27.22% and 23.67%, respectively, compared to the control group, and in group B and group D, the MDA contents in 1-day-old offspring were significantly reduced the by 24.81% and 28.17%, respectively; 4) Group B significantly down-regulated the relative expression of IL-1, IL-6, and TNF-α in the muscular stomach, and group D significantly down-regulated the relative expression of TNF-α in the muscular stomach. In conclusion, the addition of V-E and organic selenium to the diets of yellow-feathered broiler breeders could improve the reproductive performance of breeders, reduce the incidence of inflammations in muscular stomach and glandular stomach, increase the antioxidant capacity and reduce the expression of inflammatory factors in the 1-day-old chicks.