Based on reducing chemical fertilizer by 22.22% to 50.00%, Xingjia No.2 potato was used as material to study the effects of combined application of biological organic fertilizer and chemical fertilizer(T1, biological organic fertilizer 600 kg/hm2 and compound fertilizer 1125 kg/hm2), combined application of micronutrient fertilizer and chemical fertilizer (T2, micronutrient fertilizer 60 kg/hm2 and compound fertilizer 1125 kg/hm2), organic-inorganic mixed fertilizer(T3, 1500 kg/hm2), compound microbial fertilizer(T4, 1500 kg/hm2), chelated humic acid compound fertilizer (T5, 937.5 kg/hm2), conventional fertilization control(CK1, compound fertilizer 1500 kg/hm2), reduced fertilization control(CK2, compound fertilizer 1125 kg/hm2) and no fertilization control(CK3) on the growth, yield and quality of the potato. The results showed that T5, T1 and T2 could promote the growth of potato plants compared with CK1. Compared with CK1, the yield with T5, T2 and T1 increased by 19.82%, 11.65% and 8.2% respectively, and nutrient use efficiency increased by 74.87%, 57.75% and 50.52% respectively. Compared with CK1, fertilizer application in CK2 reduced by 25%, but the yield in CK2 reduced only by 3.21% while the nutrient use efficiency increased by 74.87%. There were significant differences in tuber qualities including contents of dry matter, starch, V-C, protein, potassium, reducing sugar contents among different treatments. Hence, under the condition of 25% reduction of chemical fertilizer, the application of chelated humic acid compound fertilizer and biological organic fertilizer or micronutrient fertilizer combined with compound fertilizer promoted the growth of potato plants, significantly increased the tuber yield, tuber quality, and the nutrient utilization efficiency.