In this study, 180 ICR mice were randomly and evenly divided into experimental and control group. In experimental group, two sides of ventral wall were infected the Cladosporium cladosporioides isolated from giant panda suspension(1×106 cfu/mL) in symmetrically subcutaneous way. Body condition and performance of inoculation site of the mice were observed every day after 12 h past inoculation. Finally, the mice skin tissues of the inoculated sites were used for histopathological examination and retro-culture. The number of immune cells, spores and hyphae per unit area in pathological sections was counted by Image-Pro Plus 6.0. Results showed that the change of body surface characteristics was not obvious, immune cells reduced, spores and hypha at the long stage of germination and growth gradually reduced and then increased. At 9-10 DPI, the inoculation site showed small erythema, skin nodular, no adhesion among organs and other symptoms were not obvious, and immune cells continues to increase. At 11-25 DPI the inoculation sites were proliferation, increased erythema area, deepened damage, darker color, and the mice were itchy and significantly reduced diet, and immune cells decreased gradually after continuous increase, while the number of spores and hyphae increased sharply after reduction, and then increased sharply after reduction, and there were two peaks on the 17th and 25th day. After 26 DPI mice reduced diet continuously, inoculation site appeared local necrosis and mucosal adhesion, the spores and hyphae gradually decreased. In summary, the C. cladosporioides infection mice can be grouped into for period: incubation period,1-8 DPI, prodrome period, 9-10 DPI, onset period, 11-25 DPI, and transition period, after 26 DPI.