In the study, 100 New Zealand white rabbits were randomly grouped into 5 groups, control group, model group, Chinese herb extracts treated high, medium and low dose group. Except the control group, each group of experimental rabbits infected 1×105 eggs of Eimeria intestinalis were treated with 0, 0.500, 0.250, 0.125 g/kg traditional Chinese medicine compound extract(composed of PULSATILLAE RADIX, BUPLEURI RADIX, PINELLIAE RHIZOMA, SCUTELLARIAE RADIX, ARECAE SEMEN and GLYCYRRHIZAE RADIX ET RHIZOMA) for 3 d with once per day, and 21 d continuous observation after the treatment. The observation included the every day deaths and bloody stool, the every 7 d body mass and collected dung as OPG, the caecal lesions of rabbits by dissection at the end of the test. The results showed that the survival rate of experimental rabbits treated with high-dose and medium-dose traditional Chinese medicine compound extract reached 90% and 85%, and the degree of coccidiosis infection gradually changed from severe to mild. While, the model group and low-dose group was at 25% and 50%, and most of the survival experimental rabbits were seriously infected. At 7, 14, and 21 d after the administration, the body weight of the experimental rabbits in the high-dose and middle-dose groups were significantly higher than the model group(P＜0.05), the OPG was significantly lower than the model group(P＜0.01), and the blood stool score was significantly lower than model group(P＜0.05). At the 7 d administration, only the OPG of the experimental rabbits in low-dose group was significantly lower than the model group(P＜0.01). At the 14 d administration, the body weight of the experimental rabbits in low-dose group was significantly higher than the model group(P＜0.05), the OPG was significantly lower than the model group(P＜0.01). At the 21 d administration, the body weight of the experimental rabbits in the high-dose and middle-dose groups were significantly higher than the model group(P＜0.01) and significantly lower than the low-dose group(P＜0.01), relative mass gain was significantly higher than the model group and low-dose group(P<0.01), the OPG was significantly lower than the model group and low-dose group(P＜0.01), and blood disappeared. In addition, the ACI value of the high, middle and low-dose group were significantly higher than that of the model group(P＜0.01), and the treatment effects were high, medium, and ineffective. These results indicated that the traditional Chinese medicine compound extract had a good therapeutic effect on coccidian, and the higher dose treatment has the better effect.