100 cases of African swine fever(ASF) had been found continuously in 24 provinces of China since August 2018 to January 8, 2019. At present, the epidemic is continuing and there is a potential risk of further spread to the whole country. In the view of the current status of the disease and its potential impact, based on the lessons of ASF prevention and control in other countries and taken the consideration of the situation in China, we constructed a complicated system of Trinity ASF epidemic risk prevention and control system centered on the government, pig cooperatives and pig farmers. This system, which is a dynamic interactive network with maximizing the interests of the three parties as the starting point, rational layout and organization as the main line, prevention and control business process as the core, and full symmetry of epidemic information as the final destination under the tripartite game equilibrium，to some extent, will alleviated the spread of the epidemic from the perspective of organizational structure, and prevent the epidemic originally, with a goal to achieving the strategic goal of improving the government’s ability to manage the epidemic.