In this study, one soil containing As, Cd, Zn, Pb was collected and 5 stabilizers of SiO2, CaO, CaCO3, FeSO4 and green manure were applied to the soil to investigate their soil stabilization. The results showed that when only one stabilizer was applied, FeSO4 had the most stable effect on As in the soil, and the stable effects of CaO and CaCO3 on soil Cd, Pb and Zn were relatively fine, the stable effect of green manure was the worst, and the five stabilizers were better in stabilizing the heavy metals in the soil with the increase of the proportion of addition. When the combination of two stabilizers were applied at the same time, FeSO4 with CaO and FeSO4 with CaCO3 had higher stabilization efficiency, and the application of 3%FeSO4 with 3%CaO can repair of As, Cd, Pb and Zn simultaneously. Compared with combined application of two stabilizers with different orders, when FeSO4 was added first, the stabilization efficiency of four heavy metals in the soil were 92.07%, 31.08%, 27.35% and 53.91%, while CaO was first added, the stabilization efficiency of the four heavy metals were 88.21%, 40.14%, 29.81%, 55.12%. In summary, to stabilize multiple heavy metals in soil, different formulations, ratios and the order of addition should be considered.