Acute and accumulative toxicity of compound albendazole and ivermectin were respectively researched in the paper by using BLISS and Does–Periodic–Increased methods. The test of acute toxicity result indicated that compound albendazole and ivermectin could lead mice to depression, tremor, coma, even to death, and the semilethal concentration (LD50) of the compound was 1 441.13/60.05 mg/kg. The test of accumulative toxicity result indicated that accumulation coefficient of the compound was 4.26. The weight and feed intake were significantly reduced with dose increasing, and the mice behaved with irregular hair coat and spirit depression, further with the aggravation of toxic symptoms, such as tremor, coma and even death. The results from the biochemical tests on the blood of all survival mice showed that the level of TP, ALB, URIC decreased significantly (P<0.05) compared to those in control. The same were true for testis/bodyweight (P<0.01) and spleen/bodyweight (P<0.05), on the contrary, the brain/bodyweight was increase very significantly (P<0.01); Histopathology changes were observed in brains and testis. It was concluded that the compound albendazole and ivermectin presented a moderate toxic, the main toxic symptoms brought by it was tremor, coma, as well as some neurological signs. Accumulation toxicity also presented in moderate degree by taken effects on the damage to central nervous system, liver and testis.