One hundred and eleven flue-cured tobacco samples of C3F grade were collected from main tobacco growing areas in Henan province. Tar yield and chemical components were determined to study the correlation of the spatial distribution characteristics of tar yield with chemical components. The results showed that tar yield of Henan flue-cured tobacco ranged from 16.0–22.0 mg/cigarette, and the cumulative frequency distribution was 89.19%. Tar yield of flue-cured tobacco leaves in west Henan was the highest and in south Henan the lowest. The chlorine content was the largest factor influencing the tar yield.