Cross combinations of Yunrui series sugarcane were evaluated using the grey proximity of spatial sequence through seven traits (the plant height, stem diameter, stem weight, the number of effective clusters, hammer, clump weight and hammer weight), deriving from 22 cross combinations of Yunrui series sugarcane. The results showed that the grey proximity of five combinations, including DZ93–88×YGF203–393, DZ93–88×YR99–151, YBF299–546×DZ93–94, MT90–1022×YBF204–186 and DZ93–94×YGF203–393, were larger than 0.905 9, belonged to the best combinations, which accounted for 22.7% of the tested combinations; The grey proximity of 8 combinations, including YT93–159× YR03–417, DZ93–94×YGF203–80, DZ93–88×YBF299–546, CP65–357×YR03–917, DZ93–88×YGF203–117, MT90– 1022×YGF203–392, MT90–1022×YBF299–546 and YGF203–393×MT90–1022, were between 0.812 4 and 0.893 8, belonged to the better combinations, accounting for 36.4% of the total. These excellent sugarcane hybrid combinations could be used as the key combinations for germplasm innovation and variety breeding. The remaining combinations could be individually utilized depended on breeding purposes.