The effect of seedling soaking by some sorts of medicaments for 24 h upon the yield and quality of cassava were discussed by using cassava variety of Manihot esculenta Crantz (SC8). The investigation indicated that 1.0% and 2.0% of limewater solution and 1.0% of calcium chloride solution have the higher survival than other treatments, reached 94.4%; The treatment which using 3 000 times of Yunda–120 solution grown most fast than other treatments. The treatments with 1.0%, 2.0% limewater and 1.0%, 2.0% calcium chloride may accelerate the growth of the aerial part of cassava, but the difference was not significant. The fresh root yield, dry root yield and starch yield could increase with 1.0% and 2% of limewater solution, 1.0% of calcium chloride solution, while had no effect on above three yield with clean water, 2.0% of calcium chloride and 3 000 times of Yunda–120 solution compared with the non-soaking treatment (CK). And correlation analysis indicated that fresh root yield and seed stem survival rate were very significant correlation, and that starch yield and plant fresh root weight were very significant correlation.