Soil nutrient contents in Yiliang tobacco-growing area of Yunnan province were surveyed from 2010 to 2013 and integrated fertility index (SFI value) was calculated to analyze the soil fertility suitability of this area. The result indicated that ① the pH, organic matter, hydrolytic N, rapidly available K and available B content were at an appropriate level while rapidly available P, available Mg, available Zn and water-soluble Cl– content were high, the content of available P, water-soluble Cl– had great variation; ② based on SFI, soil fertility suitability of 20% of Yiliang tobacco-growing area graded I, 47.7% graded Ⅱ, 29.3% graded Ⅲ, 1.5% graded Ⅳ and 1.5% graded V and the average SFI was 0.61; ③ from 2010 to 2013, the pH value and available Mg content reduced year by year, while the content of organic matter, hydrolytic N, rapidly available P, rapidly available K, available Zn, available B and water-soluble Cl– were increased.