A kind of Siraitia grosvenorii, Nongqing NO.2, was planted at scaffolding and trellis close planting mode in open field, to investigate its fruit number, fruit rate of various grades, as well as to test the change of mogroside V, gross sugar and vitamin C in fruit at 1 hm2 area. The results showed that the fruit number at scaffolding mode was increased by 10.8% compared with that of trellis close planting mode, but the differences among the rate of extra big size fruit, big size fruit and middle size fruit were no significance. The fruit number per hm2 at both planting mode was obviously increased with planting density, however, the rate of extra big size fruit and big size fruit were declined with the increase of planting density. There were no impact of trellis form, density and planting mode on the rate of middle size fruit and substandard fruit, while, the rate of small size fruit showed an increased trend with planting density. The content of mogroside V cultured at trellis close planting mode increased by 9.6% compared with that of cultured at scaffolding mode, however, there was no difference in content of V–C and total sugar between the two modes. The content of sweet glycosides V, total sugar and V–C increased firstly, and then decreased with planting density in both modes. Good marketing fresh quality could be acquired at scaffolding mode with the planting space at 2.0 m × 2.0 m, while good processing quality could be gotten at the planting space with 1.5 m × 2.5 m at trellis close planting mode.