In order to study the effects of different combination of organic manures and inorganic fertilizer on yield and N use efficiency of double-rice in Dongting Lake area, different treatments of field experiments were conducted, they were no fertilizer treatment (WF), no nitrogen treatment (WN), the chemical treatment (CF), 20% nitrogen fertilizer replaced by pig manure treatment (ZF), 20% nitrogen fertilizer replaced by pig compost treatment (DF), 20% nitrogen fertilizer replaced by biogas residue and slurry treatment (ZYF). The results showed that: ①Compared with chemical fertilizers, combined application of organic manure and chemical fertilizers could effectively improve rice height, panicle number, seed setting rate, and grain weight; ②Compared with that of WN and WF, the four nitrogen treatments (CF, ZF, DF and ZYF) had significant differences in annual yields, but there was no obvious difference among the four nitrogen treatments. Compared with treatment WN, the yields of treatments CF, ZF, DF and ZYF increased by 53.03%, 48.35%, 55.65% and 48.49%, respectively, among them, rice yield of treatment DF was the highest, reached up to14 039.80 kg/hm2, followed by treatment CF, reached to 13 803.43 kg/hm2; ③ The annual average nitrogen use efficiency in treatment DF was 20.23 g/kg, which was the highest, which was 11.46%, 12.64% and 14.04% higher than those in treatments CF, ZF and ZYF respectively. Compared with chemical fertilizers, combined application of organic manure and chemical fertilizers could effectively improve the yield and N use efficiency of double-rice, and treatment DF was the best one.