Based on daily temperature, precipitation and sunshine duration from 1961 to 2010 in Hunan, the climate change features closely related with the growth of tobacco in recent 50 years were analyzed using regression analysis, Mann-Kendall jump test and moving t–test and the influence of climate change on tobacco planting was discussed. The results showed that sunshine duration at field stage had decreased, with an average decrease of 10.8 h per decade; precipitation at field stage had increased, with an average increase of 6.3 mm per decade and abrupt climate change occurred in 1991; precipitation at mature stage had increased, with an average increase of 12.8 mm per decade and abrupt climate change occurred in 1989; the times of high temperature damage showed an increasing trend and the probability of this damage had increased significantly since 2000. The climate change in recent 50 years reduced the suitability of north Xiangxi tobacco area and Chenzhou tobacco area to tobacco planting and improved the tobacco planting suitability of southern Xiangxi tobacco area and Changsha tobacco area.