Orthogonal test was used to make cigarette (no flavor) using cut tobacco added with different proportions of three kinds of wires (stem wire, expansion wire and flake wire), and the contents of 3 harmful components (NH3, HCN, CO) released in mainstream smoke of cigarettes were determined. The results indicated that when mainly considering the cigarette smoke emission of NH3, the optimum proportions of stem wire, expansion wire and flake wire were 15%, 15% and 15% respectively; when mainly considering the cigarette smoke emission of HCN, the optimum proportions of stem wire, expansion wire and flake wire were 15%, 5% and 15% respectively; when mainly considering the cigarette smoke emission of CO, the optimum proportions of stem wire, expansion wire and flake wire were 15%, 15% and 0% respectively.