为提高紫苏粕的综合利用率，采用有机溶剂提取法提取紫苏粕中的天然类胡萝卜素，通过单因素试验得出适宜的提取溶剂种类、丙酮与甲醇的体积比、提取温度、提取时间、固液比(紫苏粕质量与混合液体积的比)，通过正交试验得出有机溶剂提取紫苏粕中类胡萝卜素的最佳工艺条件：丙酮与甲醇体积比为2∶1，提取温度为50 ℃，提取时间为8 h，固液比为1∶50。该浸提条件下类胡萝卜素提取率为4.0 mg/(100 g)。 Organic solvent method was optimized here to extract carotenoids from Perilla frutescens meal for the comprehensive utilization of Perilla frutescens meal. Through the single factor experiment, the influence of the extraction solvent, the ratio of acetone to methanol, the extraction temperature, the extraction time and the ratio of liquid to perilla meal respectively on the yield of carotenoids were studied. Orthogonal test indicated under the temperature of 50 ℃ and 8 h of extraction the optimum ratios of acetone to methanol(V/V) and solid to liquid(W/V) were 2∶1 and 1∶50 respectively. Under these conditions, the yield of carotenoids from Perilla frutescens meal reached 4.0 mg/(100 g).