A combined process technique for sapogenin wastewater was carried out here, in which sapogenin wastewater was pretreated by Candida utilis and retreated by DCDHCHO. The effect of the treatment and the impact factors were discussed by single factor experiments and orthogonal optimizing experiments. The main conclusions were as follows: 1) The results of the Candida utilis pretreatment indicated that the optimum temperature, pH and inoculation method were 25 ℃, pH 5.5 and inoculated at a ratio of 1∶10 respectively; 2) The results of the DCDHCHO retreatment indicated that the optimum pH, addition dosage and reaction time were pH 7, 4 mL/L and 3 min respectively；3) Under these conditions, the total removal rate of COD and colority reached 94.61 and 96.87% respectively, which met the Discharge Standard of Water Pollutants for Sapogenin Industry (GB20425—2006).