Abstract: A field plot experiment was carried out to study the effect of integrated fertilization with organic manure and chemical fertilizers on grain yield of rice, accumulation of N，P，K nutrient and nitrogen use efficiency. The study was conducted in field with eight treatments: non fetilization,organic manure, swine manure (corresponding to 10%, 20%, 30% organic manure, respectively), pig dung (corresponding to 20% organic manure), biogas slurry(corresponding to 20% organic manure), staw(corresponding to 10% organic manure), respectively. Results showed that the combined application of pig manure compost and inorganic fertilizers increased the grain number per panicle and the grain yield of rice, promoted rice nutrient accumulation, and improved nitrogen efficiency. The rice yield of treatment of pig manure compost instead of 20% pure fertilizer is the highest(5 662.4 kg/hm2) and the yield increased 8.5% compared with pure fertilizer treatment. In the late rice, the rice yield in the treatments of pig manure compost instead of 10%, 20%, 30% pure fertilizer increased 12.5%, 11.6% and 5.8% respectively than that in the pure fertilizer treatment. Rice nitrogen use efficiency is the highest in the treatment of pig manure compost instead of 20% pure fertilizer.