The compound 5-O-octadecanoyl-1,2-O-isopropylidene-α-D-xylofuranose was synthesized using 4-DMAP as catalyst and DCC as dehydration reagent. Its structure was confirmed by IR, 1H NMR, MS spectra and elemental analysis. The pyrolysis of the precursor and the application of the compound in blended cigarette flavoring were studied as well. The results showed that the synthesized compound gave off typical flavors of hexadecanoic acid to the smoke of cigarette.