8 microsatellite markers linked with Escherichia-coli F4 receptor gene were selected from chromosome 13 of swine to analyze difference in hereditary between the genotype and F4 receptor adhesive appearance. Results showed that the microsatellite markers were highly polymorphic and the heterozygosities ranged from 0.6117 to 0.7500. The value of PIC was over 0.5749 and the heredity diversity of chinese pig breeds more higher than oversea’s.There were signficiant difference between genotypes and F4ab and F4ac adhesive in microsatellite S0223 and SW207in two breeds, which indicated the F4ab and F4ac receptors gene located in the two loci. S0223 and SW207 can thus be potentially used as a genetic marker for E. coli F4 resistive gene.