The technics of purification of proanthocyanidins from grape (Vitis davidii Foëx) seeds were studied. Resin was chosen by orthogonal experiment, capability of adsorption and desorption and effect factors of proanthocyanidins on resins were reviewed, the best conditions for adsorption and desorption on the chosen resin of proanthocyanidins were researched. The result were as follows: the best chosen resin was YWD-06C, the optimal adsorption conditions were: temperature, 20 ℃, adsorption time, 6 h, pH, 4；the optimal desorption conditions were: solvent 60% ethanol, pH, 4, desorption time, 6 h, temperature, 25 ℃; the adsorption speed, 4 BV/h and the desorption speed, 2 BV/h, which were established by dynamic testing. The content of proanthocyanidins after purfication reached 92.57%.